To configure Apache to work with PyKwiki, you'll need a virtual host entry for static files that points to the PyKwiki install.
For example, if your project directory is /home/hpotter/pykwiki/MyBlog, then a virtual host entry might appear as follows:
<VirtualHost *:80> ServerName www.myblog.com DocumentRoot "/home/hpotter/pykwiki/MyBlog/docroot/" ErrorDocument 404 /404.html <Directory "/home/hpotter/pykwiki/MyBlog/docroot/"> RewriteEngine Off Options Indexes FollowSymLinks MultiViews AllowOverride None Order allow,deny allow from all </Directory> </VirtualHost>